MEGAResFrom MEG, the Microbial Ecology Group

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Aminoglycoside O-phosphotransferases

Resistance to aminoglycosides is commonly caused by modification of the drug itself via O-phosphoylation, O-nucleotidylation, and N-acetylation. Aminoglycoside O-phosphotransferases transfer a phosphate from ATP to a specific hydroxyl group on the aminoglycoside molecule. This confers resistance by drug modification.

References

  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC372903/pdf/microrev00024-0152.pdf

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Other Mechanisms in Aminoglycosides

Groups

Sequences

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