MEGAResFrom MEG, the Microbial Ecology Group

Aminoglycoside O-phosphotransferases

Resistance to aminoglycosides is commonly caused by modification of the drug itself via O-phosphoylation, O-nucleotidylation, and N-acetylation. Aminoglycoside O-phosphotransferases transfer a phosphate from ATP to a specific hydroxyl group on the aminoglycoside molecule. This confers resistance by drug modification.

References

Other Mechanisms in Aminoglycosides

Groups

Sequences

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