MEGAResFrom MEG, the Microbial Ecology Group

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ANT4-PRIME

Aminoglycoside O-nucleotidyltransferases transfer a nucleoside triphosphate to the aminoglycoside, which results in resistance by drug modification. Ant(4') nucleotidyltransferases modify the 4 prime functional group.

References

  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC372903/pdf/microrev00024-0152.pdf

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Other Groups in Aminoglycoside O-nucleotidyltransferases

Sequences

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>>MEG_976|Drugs|Aminoglycosides|Aminoglycoside_O-nucleotidyltransferases|ANT4-PRIME
atgaaaggaccaataataatgactagagaagaaagaatgaagattgttcatgaaattaaggaacgaatattggataaata
tggggatgatgttaaggcaattggtgtttatggctctcttggtcgtcagactgatgggccctattcggatattgagatga
tgtgtgttctgtcaacagagggagtagagttcagctatgaatggacaaccggtgagtggaaggcggaagtgaatttttat
agcgaagagattctactagattatgcatctcgggtggaaccggattggccgcttacacatggtcgatttttctctatttt
gccgatttatgatccaggtggatactttgagaaagtgtaccaaactgctaaatcggtagaagcccaaaagttccacgatg
cgatctgtgcccttatcgtagaagagctgtttgaatatgcaggcaaatggcgtaatattcgtgtgcaaggaccgacaaca
tttctaccatccttgactgtacaggtggcaatggcaggtgccatgttgattggtctgcatcatcgcatctgttatacgac
gagcgcttcggtcttaactgaagcagttaagcaaccagatcttcctccaggttatgtccaactgtgccagctcgtaatgt
ctggtcaactttccgaccctgagaaacttctggaatcgctagagaatttctggaatggggttcaggagtgggcggaacga
cacggatatatagtggatgtgtcaaaacgcataccattttga

>>MEG_977|Drugs|Aminoglycosides|Aminoglycoside_O-nucleotidyltransferases|ANT4-PRIME
atgaacatgaatggacctgtaaaaatttctcgaagtgaacgatttcaaacctgccaagaaattgctgcgagattgcatga
agtgtacaaagaaaaaattctggccattggggtgtatggttctatttctcgtgggacagacggcccttattcggatatcg
agatgttttgtgtactagaagaaacaggggaagaaatagaatttagctacgaatggtcagcgggaccttggaaggcggaa
gtgaatgtgtgcagtgcagatgttttgctgaacactgcgtctactgtcgaggatgattggccgctgacacatggcccatt
cttttctccgctgagtctgtacgatccgaagggctttttggaaacgctcaaaaaagcagcggaatcaccgtcgcaggaag
agttcacagagaatatcaacggtattctcgtaggggaaatgtacgagtttattggcaagttgcgaaacgtaaatctagac
ggcccacatacctatctgccttacttggctatggagtttgcccaatatggtgcgatgttgatcgggctgcataaccgaaa
gctctactcgacaggggccaaggttttgccagaagcgctggaattgccgcatcgcccggctggatacgatcaggtagcca
gattggtaatggcgggggatctgactgatccagcaaaaatcgttaccgcttgcgaagcattctgggatggtctccaagag
tgggctgcacaacatcactatgtgattcattcagagcgaattcctttttaa

>>MEG_978|Drugs|Aminoglycosides|Aminoglycoside_O-nucleotidyltransferases|ANT4-PRIME
atgagaatagtgaatggaccaataataatgactagagaagaaagaatgaagattgttcatgaaattaaggaacgaatatt
ggataaatatggggatgatgttaaggctattggtgtttatggctctcttggtcgtcagactgatgggccctattcggata
ttgagatgatgtgtgtcatgtcaacagaggaagcagagttcagccatgaatggacaaccggtgagtggaaggtggaagtg
aattttgatagcgaagagattctactagattatgcatctcaggtggaatcagattggccgcttacacatggtcaattttt
ctctattttgccgatttatgattcaggtggatacttagagaaagtgtatcaaactgctaaatcggtagaagcccaaaagt
tccacgatgcgatttgtgcccttatcgtagaagagctgtttgaatatgcaggcaaatggcgtaatattcgtgtgcaagga
ccgacaacatttctaccatccttgactgtacaggtagcaatggcaggtgccatgttgattggtctgcatcatcgcatctg
ttatacgacgagcgcttcggtcttaactgaagcagttaagcaatcagatcttccttcaggttatgaccatctgtgccagt
tcgtaatgtctggtcaactttccgactctgagaaacttctggaatcgctagagaatttctggaatgggattcaggagtgg
acagaacgacacggatatatagtggatgtgtcaaaacgcataccattttga

>>MEG_979|Drugs|Aminoglycosides|Aminoglycoside_O-nucleotidyltransferases|ANT4-PRIME
gtgaatggaccaataataatgactagagaagaaagaatgaagattgttcatgaaattaaggaacgaatattggataaata
tggggatgatgttaaggctattggtgtttatggctctcttggtcgtcagactgatgggccctattcggatattgagatga
tgtgtgtcatgtcaacagaggaagcagagttcagccatgaatggacaaccggtgagtggaaggtggaagtgaattttgat
agcgaagagattctactagattatgcatctcaggtggaatcagattggccgcttacacatggtcaatttttctctatttt
gccgatttatgattcaggtggatacttagagaaagtgtatcaaactgctaaatcggtagaagcccaaaagttccacgatg
cgatttgtgcccttatcgtagaagagctgtttgaatatgcaggcaaatggcgtaatattcgtgtgcaaggaccgacaaca
tttctaccatccttgactgtacaggtagcaatggcaggtgccatgttgattggtctgcatcatcgcatctgttatacgac
gagcgcttcggtcttaactgaagcagttaagcaatcagatcttccttcaggttatgaccatctgtgccagttcgtaatgt
ctggtcaactttccgactctgagaaacttctggaatcgctagagaatttctggaatgggattcaggagtggacagaacga
cacggatatatagtggatgtgtcaaaacgcataccattttga

>>MEG_980|Drugs|Aminoglycosides|Aminoglycoside_O-nucleotidyltransferases|ANT4-PRIME
gtgaatggaccaataataatgactagagaagaaagaatgaagattgttcatgaaattaaggaacgaatattggataaata
tggggatgatgttaaggctattggtgtttatggctctcttggtcgtcagactgatgggccctattcggatattgagatga
tgtgtgtcatgtcaacagaggaagcagagttcagccatgaatggacaaccggtgagtggaaggtggaagtgaatttttat
agcgaagagattctactagattatgcatctcaggtggaatcagattggccgcttacacatggtcaatttttctctatttt
gccgatttatgattcaggtggatacttagagaaagtgtatcaaactgctaaatcggtagaagcccaaaagttccacgatg
cgatttgtgcccttatcgtagaagagctgtttgaatatgcaggcaaatggcgtaatattcgtgtgcaaggaccgacaaca
tttctaccatccttgactgtacaggtagcaatggcaggtgccatgttgattggtctgcatcatcgcatctgttatacgac
gagcgcttcggtcttaactgaagcagttaagcaatcagatcttccttcaggttatgaccatctgtgccagttcgtaatgt
ctggtcaactttccgactctgagaaacttctggaatcgctagagaatttctggaatgggattcaggagtggacagaacga
cacggatatatagtggatgtgtcaaaacgcataccattttga

>>MEG_981|Drugs|Aminoglycosides|Aminoglycoside_O-nucleotidyltransferases|ANT4-PRIME
ATGAGAATAGTGAATGGACCAATAATAATGACTAGAGAAGAAAGAATGAAGATTGTTCATGAAATTAAGGAACGAATATT
GGATAAATATGGGGATGATGTTAAGGCTATTGGTGTTTATGGCTCTCTTGGTCGTCAGACTGATGGGCCCTATTCGGATA
TTGAGATGATGTGTGTCATGTCAACAGAAGAAGCAGAGTTCAGCCATGAATGGACAACCGGTGAGTGGAAGGTGGAAGTG
AATTTTGATAGCGAAGAGATTCTACTAGATTATGCATCTCAGGTGGAATCAGATTGGCCTCTTACACATGGTCAATTTTT
CTCTATTTTGCCGATTTATGATTCAGGTGGATACTTAGAGAAAGTGTATCAAACTGCTAAATCGGTAGAAGCCCAAACGT
TCCACGATGCGATTTGTGCCCTTATCGTAGAAGAGCTGTTTGAATATGCAGGCAAATGGCGTAATATTCGTGTGCAAGGA
CCGACAACATTTCTACCATCCTTGACTGTACAGGTAGCAATGGCAGGTGCCATGTTGATTGGTCTGCATCATCGCATCTG
TTATACGACGAGCGCTTCGGTCTTAACTGAAGCAGTTAAGCAATCAGATCTTCCTTCAGGTTATGACCATCTGTGCCAGT
TCGTAATGTCTGGTCAACTTTCCGACTCTGAGAAACTTCTGGAATCGCTAGAGAATTTCTGGAATGGGATTCAGGAGTGG
ACAGAACGACACGGATATATAGTGGATGTGTCAAAACGCATACCATTTTGA

>>MEG_982|Drugs|Aminoglycosides|Aminoglycoside_O-nucleotidyltransferases|ANT4-PRIME
GTGCAACATACTATCGCCCGTTGGGTTGATCGCCTTCGCGAGGAGTACGCCGATGCCGTCGCGATTCTACTGAAGGGCAG
TTACGCCCGGGGCGATGCTGCGACGTGGAGCGATATCGATTTCGATGTATTGGTAAGCACGCAGGATGTGGAGGATTACC
GCACCTGGATAGAGCCGGTCGGCGATCGGCTGGTGCATATCTCGGCGGCGGTCGAGTGGGTCACCGGTTGGGAGCGCGAT
ACCGTCGATCCATCCAGTTGGAGTTACGGCCTGCCAACGCAGGAAACCACCCGACTTATGTGGGCGATTAATGACGAGAC
TCGGCGGCGCATGGATCGTCCTTACAAAACGCATCCGGCCGCCGAACCCGAGGTGGAGAATACCGTTGAGGCGCTAGGCA
AAATTCGCAATGCCATTGCTCGCGGCGATGACCTGGGCGTGTATCAATCCGCACAGACCGTGGCAAAGTTAGTGCCGACA
TTGTTGATCCCCATCAATCCACCGGTGACCGTGTCGCACGCACGGCAGGCGATCGAGGCGATTCTCGCGTTTCCCCGCGT
GCCCGTGGGGTTTGCAGCAGATTGGCTCACCTGCCTCGGATTGGTGGAAGAGCGAAGTGCGCGCTCGACCGCCGCAGCGG
CCGAGCGCATGGTTCGTGGCGTGCTCGAAATGCTCCCTACCGATCCCGACCTCCTAGGCGAGGATATCGCCCGATTGATG
AACGCCGGGTTGCTCGAGAAATACGTGCAGCAGTGA

>>MEG_983|Drugs|Aminoglycosides|Aminoglycoside_O-nucleotidyltransferases|ANT4-PRIME
GTGAATGGACCAATAATAATGACTAGAGAAGAAAGAATGAAGATTGTTCATGAAATTAAGGAACGAATATTGGATAAATA
TGGGGATGATGTTAAGGCTATTGGTGTTTATGGCTCTCTTGGTCGTCAGACTGATGGGCCCTATTCGGATATTGAGATGA
TGTGTGTCATGTCAACAGAGGAAGCAGAGTTCAGCCATGAATGGACAACCGGTGAGTGGAAGGTGGAAGTGAATTTTGAT
AGCGAAGAGATTCTACTAGATTATGCATCTCAGGTGGAATCAGATTGGCCGCTTACACATGGTCAATTTTTCTCTATTTT
GCCGATTTATGATTCAGGTGGATACTTAGAGAAAGTGTATCAAACTGCTAAATCGGTAGAAGCCCAAACGTTCCACGATG
CGATTTGTGCCCTTATCGTAGAAGAGCTGTTTGAATATGCAGGCAAATGGCGTAATATTCGTGTGCAAGGACCGACAACA
TTTCTACCATCCTTGACTGTACAGGTAGCAATGGCAGGTGCCATGTTGATTGGTCTGCATCATCGCATCTGTTATACGAC
GAGCGCTTCGGTCTTAACTGAAGCAGTTAAGCAATCAGATCTTCCTTCAGGTTATGACCATCTGTGCCAGTTCGTAATGT
CTGGTCAACTTTCCGACTCTGAGAAACTTCTGGAATCGCTAGAGAATTTCTGGAATGGGATTCAGGAGTGGACAGAACGA
CACGGATATATAGTGGATGTGTCAAAACGCATACCATTTTGA

>>MEG_984|Drugs|Aminoglycosides|Aminoglycoside_O-nucleotidyltransferases|ANT4-PRIME
ATGCACCTCACCATTACCTACTGGATCGATCGTCTGCGAGAAGCGTATCCCCATGCGGTCGCGATTTTGCTGAAGGGAAG
CTATGCCCGGGGCGAGGCGAGTGCGTGGAGCGATATCGATTTCGATGTGCTCGTGAGCGACGAGGAAGTGGAGGAGTATC
GCACCTGGATCGAGCCTGTGGGCGAGCGGCTGGTGCATATCTCGGTCGCGGTGGAGTGGGTCACCGGGTGGGAGCGCGAT
TCGGCAGATCCATCGAGTTGGAGTTATGGCCTGCCTACGCAGGAGACCACCCAGCTGCTTTGGGCAGCTGATGAGAATAT
TCGCCGACGTCTCGATCGACCGTTCAAGGTGCATCCGGCCGCCGAACCAGAGGTGGAAGACACGGTAGAAGCGCTCGGGA
AGATCCGGAATGCGATGGTTCGGGGTGACGACCTTGCGGTCTATCAAGCTGCGCAGGTCGTGGGGAAATTGATTCCGACA
CTCCTGGTTCCCATCAATCCGCCCACGTACGCACGGTTCGCACGCGAGGCGATCGACAGGATTCTCGCCTTCCCGAATGT
ACCCGAAGGGTTCGCGGCCGATTGGCTGACGTGCATGGGTCTGGTCGATCGGCGGACGCACGATCCACAGCCGACGCGGC
CGAACGAATGGTGCGCGGCACGATCTCGCTTCTGCCGGCGGATGCGGACATCGTCGGTGAGGATATCGCGCGGTTGCTGG
AAGCAGGATTGGTACTTGCGTATATCGGCCAGAACGTGA

>>MEG_985|Drugs|Aminoglycosides|Aminoglycoside_O-nucleotidyltransferases|ANT4-PRIME
ATGCACCTTGAACGGTCGATCGAGACGTCGGCGAATATTCTCATCAGCTGCCCAAAGCAGCTGGGTGGTCTCCTGCGTAG
GCAGGCCATAACTCCAACTCGATGGATCTGCCGAATCGCGCTCCCACCCGGTGACCCACTCCACCGCGACCGAGATATGC
ACCAGCCGCTCGCCCACAGGCTCGATCCAGGTGCGATACTCCTCCACTTCCTCGTCGCTCACGAGCACATCGAAATCGAT
ATCGCTCCACGCACTCGCCTCGCCCCGGGCATAGCTTCCCTTCAGCAAAATCGCGACCGCATGGGGATACGCTTCTCGCA
GACGATCGATCCAGTAGGTAATGGTGAGGTGCATGCAAAACTCTTCAGAATGCGGACGTTGATCGTCCTGCGACTATGCC
ACCATTGTGGTGTTGATGGAGGCAACATGCCAGAACGAACACTCACACTTCGAGAACTCAACCGCACCCATTTGCAGCGA
CAACACCTGCCGAAGCTT