MEGAResFrom MEG, the Microbial Ecology Group

Aminoglycoside O-nucleotidyltransferases

Resistance to aminoglycosides is commonly caused by modification of the drug itself via O-phosphoylation, O-nucleotidylation, and N-acetylation. Aminoglycoside O-nucleotidyltransferases transfer a nucleoside triphosphate to the aminoglycoside, which results in resistance by drug modification. Other common names for this type of aminoglycoside modifying enzyme include adenyltransferase, and adenylyltransferase.


Other Mechanisms in Aminoglycosides



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