MEGAResFrom MEG, the Microbial Ecology Group

Aminoglycoside-resistant 16S-23S rRNA O-methyltransferases

An uncommon mechanism of resistance can result when a loss-of-function mutation occurs in the tlyA gene, which encodes a putative rRNA methyltransferase. The resulting effect on the rRNA of the small ribosomal subunit results in reduced binding of aminoglycoside drugs that utilize the tlyA methylation sites.


Other Mechanisms in Aminoglycosides



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