MEGAResFrom MEG, the Microbial Ecology Group

Aminocoumarins

The aminocoumarin antibiotics are derived from Streptomycetes bacteria. Their method of action is the competitive inhibition of bacterial DNA topoisomerases (typically the ATP-binding subunit), which are vital enzymes for cellular function. Common drugs in the Aminocoumarin class (coumarin glycosides) include novobiocin, clorobiocin, and coumermycin A1.

References

Mechanisms

Sequences

Download Sequences