MEGAResFrom MEG, the Microbial Ecology Group

Aminocoumarins

The aminocoumarin antibiotics are derived from Streptomycetes bacteria. Their method of action is the competitive inhibition of bacterial DNA topoisomerases (typically the ATP-binding subunit), which are vital enzymes for cellular function. Common drugs in the Aminocoumarin class (coumarin glycosides) include novobiocin, clorobiocin, and coumermycin A1.

References

  • http://www.ncbi.nlm.nih.gov/pubmed/22644392,http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189412/

Mechanisms

Sequences

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